Parkinson’s disease (PD) is a neurodegenerative disease which is clinically characterized by resting tremor, bradykinesia, rigidity and postural instability. The present study is carried out to investigate the effect of methanolic extract of Juniperus communis (MEJC) leaves on reserpine induced catalepsy in rats. Catalepsy was induced by intra peritoneal (i.p) administration of reserpine (2.5 mg/kg, i.p.). The methanolic extract at 100 and 200 mg/kg (i.p.) were screened for its efficacy against reserpine induced catalepsy in rats. The MEJC extract was found to reduce catalepsy significantly (p<0.001) as compared to the reserpine treated rats, maximum reduction was observed at a dose of 200 mg/kg. Thus the present study reveals the efficacy of MEJC in catalepsy.
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